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总状毛霉对17α-羟基孕甾-4-烯-3,20-二肟的生物转化
引用本文:谢春清,佟国军,葛文中.总状毛霉对17α-羟基孕甾-4-烯-3,20-二肟的生物转化[J].黑龙江八一农垦大学学报,2016(4):75-78.
作者姓名:谢春清  佟国军  葛文中
作者单位:1. 黑龙江八一农垦大学生命科学技术学院,大庆,163319;2. 黑龙江八一农垦大学动物科技学院
基金项目:黑龙江省教育厅项目(12521384)
摘    要:为了获得具有较强生物学活性或结构新颖的羟基甾体肟衍生物,利用总状毛霉对合成的17α-羟基孕甾-4-烯-3,20-二肟进行转化研究。转化产物经柱层析分离纯化后鉴定为7α,17α-二羟基-20-肟-孕甾-4-烯-3-酮(3)和11α,17α-二羟基-20-肟-孕甾-4-烯-3-酮(4)。目前微生物转化甾体研究领域对于甾体肟的转化研究少见报道,研究结果为甾体肟衍生物的发展奠定了基础。

关 键 词:生物转化  合成  甾体肟  羟基化  总状毛霉

Biotransformation of 17α-hydroxy-pregane-4-ene-3,20-dioxime by Mucor racemosus
Xie Chunqing;Tong Guojun;Ge Wenzhong.Biotransformation of 17α-hydroxy-pregane-4-ene-3,20-dioxime by Mucor racemosus[J].Journal of Heilongjiang August First Land Reclamation University,2016(4):75-78.
Authors:Xie Chunqing;Tong Guojun;Ge Wenzhong
Institution:Xie Chunqing;Tong Guojun;Ge Wenzhong;College of Life Science and Technology,Heilongjiang Bayi Agricultural University;College of Animal Science and Technology,Heilongjiang Bayi Agricultural University;
Abstract:In order to get strong biological activity or novel structure of oxime-steroids,the biotransformation of 17α-hydroxy-pregane-4-ene-3,20-dioxime by mucor racemosus was studied. The transformation products were purified with column chromatography and determined as 7α,17α-dihydroxy-20-oxime-4-en-3-one(3)and 11α,17α-dihydroxy-20-oxime-4-en-3-one (4). The transformation of oxime-steroids rarely occured in microbial transformations of steroid,based on the best of our knowledge, the results lay a foundation for rich diversities of oxime-steroids.
Keywords:biotransformation  synthesize  oxime-steroids  hydroxylation  mucor racemosus
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