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Leptin长型受体与神经肽Y在猪前脑内共存
引用本文:樊明欣,雷治海,李庆梅,王红星.Leptin长型受体与神经肽Y在猪前脑内共存[J].南京农业大学学报,2003,26(4):90-92.
作者姓名:樊明欣  雷治海  李庆梅  王红星
作者单位:南京农业大学动物医学院,江苏,南京,210095
基金项目:国家自然科学基金资助项目 (3 9970 5 5 5 )
摘    要:用原位杂交与免疫组织化学相结合的方法研究了 5头三元杂交仔猪前脑内leptin长型受体mRNA与神经肽Y(NPY)免疫反应阳性物质的共存关系。实验结果表明 ,leptin长型受体mRNA和NPY免疫反应阳性神经元分布于下丘脑漏斗核和前室周核、海马、杏仁核及大脑皮质。上述结构内一些表达leptin长型受体mRNA的神经元也含有NPY免疫反应阳性物质 ,即leptin长型受体与NPY共存于同一神经元内。提示leptin可能通过下丘脑漏斗核和室周核以及边缘系统的海马和杏仁核 ,甚至大脑皮质中表达leptin长型受体mRNA的NPY免疫反应阳性神经元调节动物的摄食、能量代谢、生长和繁殖等活动。

关 键 词:leptin长型受体  神经肽Y(NPY)  原位杂交  免疫组织化学  
文章编号:1000-2030(2003)04-0090-03
修稿时间:2002年12月29

Coexistence of leptin long form receptor and neuropeptide Y in the forebrain of pig
FAN Ming-xin,LEI Zhi-hai,LI Qing-mei,WANG Hong-xing.Coexistence of leptin long form receptor and neuropeptide Y in the forebrain of pig[J].Journal of Nanjing Agricultural University,2003,26(4):90-92.
Authors:FAN Ming-xin  LEI Zhi-hai  LI Qing-mei  WANG Hong-xing
Abstract:Combination of in situ hybridization and immunohistochemistry methods was used to investigate coexistence of the long form leptin receptor(OB-Rb)mRNA and neuropeptide Y-like immunoreactivity(NPY-IR)in neurons of the pig forebrain.The results showed that both OB-Rb mRNA and NPY-IR containing neurons were seen in the infundibular nucleus and periventricular nucleus in the hypothalamus,hippocampal formation,amygdala and cortex of the pig forebrain,and that some of neurons expressing OB-Rb mRNA also contained NPY-IR.It meant coexistence of OB-Rb and neuropeptide Y in these neurons of the pig forebrain.The results suggested that leptin may exert control of food intake,energy metabolism,growth and reproduction through the NPY neurons expressing OB-Rb.
Keywords:leptin long form receptor  neuropeptide Y(NPY)  in situ hybridization  immunohistochemistry  pig
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