| Cry毒素毒杀昆虫中肠细胞的机制:穿孔细胞膜还是启动细胞死亡信号途径? |
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| 引用本文： | 崔金杰,李国清.Cry毒素毒杀昆虫中肠细胞的机制:穿孔细胞膜还是启动细胞死亡信号途径?[J].南京农业大学学报,2010,33(5). |
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| 作者姓名： | 崔金杰 李国清 |
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| 作者单位： | 1. 中国农业科学院棉花研究所/农业部棉花遗传改良重点开放实验室,河南,安阳,455000
2. 南京农业大学植物保护学院/农业部作物病虫害监测与防控重点开放实验室,江苏,南京,210095 |
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| 基金项目： | 国家转基因生物新品种培育重大专项课题(2008X08011-002) |
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| 摘 要： | Cry毒素毒杀昆虫中肠细胞的机制有两种假说。传统假说认为Cry毒素插入细胞膜后形成孔洞,改变中肠细胞渗透压而杀死细胞。最近提出了另一种假说,认为Cry毒素与膜上受体钙黏蛋白结合后,激活G蛋白和腺苷酸环化酶而合成环腺苷酸,高浓度环腺苷酸顺次激活蛋白激酶A,促进胞内钙黏蛋白外移至细胞膜,从而招募和结合更多的毒素单体,正反馈放大细胞死亡信号途径,导致细胞死亡。
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| 关 键 词： | Cry毒素 毒杀机制 孔洞 信号途径 |
Intoxication mechanisms of Cry toxins to insect midgut cells: punching hole or signaling? |
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| CUI Jin-jie,LI Guo-qing.Intoxication mechanisms of Cry toxins to insect midgut cells: punching hole or signaling?[J].Journal of Nanjing Agricultural University,2010,33(5). |
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| Authors: | CUI Jin-jie LI Guo-qing |
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| Institution: | CUI Jin-jie1,LI Guo-qing2* ( 1. Cotton Research Institute/Key Laboratory of Cotton Genetic Improvement,Ministry of Agriculture,Chinese Academy of Agricultural Sciences,Anyang 455000,China,2. College of Plant Protection/Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | Two models have been proposed to describe the mode of action of Cry toxins. It has traditionally been believed that Cry toxins form ionic pores following insertion into the membrane,cause the osmotic lysis of midgut epithelial cells and induce cell death. However,an alternative model has been proposed recently. It is considered that the binding of Cry toxin monomer to cadherin activates a G protein,which in turn activates an adenylyl cyclase promoting the production of intracellular cAMP. The increased cAMP... |
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| Keywords: | Cry toxin intoxication mechanism pore signal pathway |
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