两种油脂对小鼠皮肤创伤修复作用研究

本研究旨在观察阿勒泰大尾羊尾脂油脂对损伤皮肤是否具有修复作用，并与牛油脂、市售商品做比较。研究选择40 只体重在31 ± 1 g 之间的昆明小鼠，雌雄各半，通过构建小鼠皮肤损伤模型，将小鼠分为4 组（羊尾油组、牛油组、市售商品组和空白组）进行试验观察。小鼠皮肤伤口愈合良好，雌鼠的创面愈合能力强于雄鼠，雌鼠伤口愈合速度：羊尾油组＞牛油组＞市售商品组＞空白对照组。雄鼠伤口愈合速度：羊尾油组＞市售商品组＞牛油组＞空白对照组。皮肤组织病理学结果显示，涂抹羊尾脂、牛油脂、市售商品与空白对照处皮肤相比，创伤修复组织中脂肪细胞、胶原纤维以及其他细胞的数量、排列分布均有差异。羊尾油和牛油均有修复皮肤创伤的作用，且羊尾油修复作用更强，羊尾油可通过促进胶原纤维的生成加速皮肤修复。

Effects of Two Kinds of Lipids on Wound Healing of Mice Skin

The study aims at exploring the role of the tail lipids of Altay sheep in wound healing of skin, and comparing its healing effect with that of the cattle lipids and commercial products. Forty Kunming mice weighing 31 ± 1 g, half male and half female were selected. The wound models of mice skin were constructed, and then these mice were divided into four groups (sheep lipids group, cattle lipids group, commercial product group and blank control group). The wounds healed well after different treatments, the wound healing ability of female mice were better than that of the males, and the wound healing rates of female mice were: sheep lipids > cattle lipids > commercial product > blank control group, whereas those of the male mice were: sheep lipids > commercial product > cattle lipids > blank control group. The results of skin histopathology showed that compared with the blank control group, in the other three groups, the quantities and distribution of adipose cell, collagen fibrils and other cells in wound repair tissue were different. Both the sheep tail lipids and the cattle lipids have effects on repairing skin injury, and the sheep tail lipids have the better one. The sheep tail lipids can accelerate the skin repair by promoting collagen fibers producing.