利用正交实验设计研究磺胺甲恶唑在渔业水体中的消解动态规律

为了探究磺胺甲恶唑(sulfamethoxazole,SMZ)在渔业水体中的自然降解规律,本试验选取了养殖水环境中常见的因素(温度、pH和敞蔽条件),通过正交实验探究这三个因素对SMZ在自然养殖水体中消解动态的影响。试验初期各处理SMZ浓度保持一致,实验周期内定期取水样检测水体中SMZ的浓度变化,符合一级反应动力学方程,计算各处理中SMZ药物的半衰期和消除率。结果表明,18个处理组SMZ的半衰期及其消除率变化范围为4.88-12.89d,28%-77%。方差分析得出：在实验水平范围内,温度、pH因素对SMZ的消解结果有显著影响,但敞蔽的影响较小,因此提高养殖水体高温度、调节酸碱性pH等条件均有利于促进SMZ的降解。

Sulfamethoxazole in Aquaculture Water by Orthogonal Experimental Design: Degradation Dynamics

In order to explore the natural degradation rule of sulfamethoxazole (SMZ) in aquaculture water, this experiment selected common factors in aquaculture water environmental (temperature, pH and open or cover system conditions), and explored influence of these three factors on the dynamic digestion of SMZ in natural aquaculture water through orthogonal experiment. The SMZ concentration of each treatment remained consistent in the initial stage of the experiment. Water samples were taken regularly to detect the change of SMZ concentration in water body, which is consistent with the first-order kinetic equation,and the half-life and elimination rate of SMZ in each treatment were calculated. The results showed that the variation range of SMZ half-life and its elimination rate in 18 treatment groups was 4.88-12.89-d, 28%-77%. Anova analysis showed that within the range of the experimental level, temperature and pH factors had a significant influence on SMZ elimination, but the influence of the open or cover condition was small. Therefore, properly adjusting the conditions of temperature and pH of aquaculture water was conducive to promoting SMZ degradation.