三类中药制剂对急性肾衰影响的比较

为了研究瘟清注射液、香丹注射液和术苓注射液对内毒素所致急性肾衰家兔的防治作用。将40只健康哈尔滨白兔随机分为阴性对照组、模型组、瘟清组、香丹组和术苓组,每组8只。模型组和各防治组家兔一次性静脉注射大肠杆菌O111B4内毒素生理盐水溶液;三防治组家兔在注射内毒素后立即静脉注射相应的中药注射液;阴性对照组静注生理盐水。各组家兔静注液体的总量相等。注射内毒素（或生理盐水）1 h后开始通过膀胱瘘管收集尿液,每小时收集1次,共收集6 h。末次收集尿液后心脏采血。对各组家兔的肾功能指标进行动态测定。结果显示：模型组家兔发生了急性肾功能衰竭。和模型组比较,瘟清组家兔的肌酐、尿素氮排出量显著或极显著增加（P〈0.05,P〈0.01）,肾衰指数和钠排泄分数显著或极显著降低（P〈0.05,P〈0.01）,内生性肌酐清除率显著或极显著升高（P〈0.05,P〈0.01）。除肾衰指数和钠排泄分数之外,香丹组家兔绝大多数肾功能指标的变化趋势与瘟清组相似。试验结果表明：瘟清注射液对急性肾衰具有确实的防治作用;香丹注射液亦有良好的防治急性肾衰作用;术苓组家兔肾功能衰竭状况并未得到根本好转。

Comparative on Effects of three Traditional Chinese Medicine Preparations on Acute Renal Failure

The preventive and therapeutic effects of three traditional Chinese medicine preparations, i.e. Wenqing （WQ）, Xiangdan （XD） and Zhuling （ZL） injections, on endotoxin （ET）-induced acute renal failure （ARF） were investigated in Harbin white rabbit. Forty rabbits were randomly divided into five groups, namely negative control, model, WQ, XD and ZL, eight for each group. The rabbits, except those of negative control group, were given an intravenous injection of E. coli 0111B4 ET solution. After the injection of ET, the rabbits of WQ, XD and ZL groups were immediately injected corresponding preparations. The negative control rabbits were given an intravenous injection of normal saline （NS）. Liquid injected in every group was balanced in volume. An hour after the injection of ET solution or NS, serial urine samples were collected by a bladder fistula at one time per hour for six hours. After the collection of the urine samples, bleeding was immediately made from heart. To ascertain the preventive effect, the renal functional parameters were measured dynamically in the rabbits of each group. The results indicated that model rabbits developed ARF. However, in the rabbits treated with WQ, urinary output, the excretion of creatinine, urea nitrogen and sodium were significantly increased （P〈0.05, P〈0.01）, renal failure index and the fractional excretion of sodium were markedly decreased （P〈0.05, P〈0.01）, endogenic creatinine clearance was significantly increased （P〈0.05, P〈 0.01）.The changes of the renal functional parameters of XD group animals, except renal failure index and thefractional excretion of sodium, were similar to those of WQ group. It could be concluded that WQ had obvious preventive and therapeutic effect on ARF induced by ET; XD had also good preventive and therapeutic effect on ET-induced ARF; but ZL group rabbits were not halted completely on ET-induced ARF.