土霉素在大菱鲆体内药代动力学及残留消除规律研究

摘要：首次研究大菱鲆口服土霉素的药代动力学特征及残留消除规律。采用高效液相色谱法，对以80 mg/kg b.w.单剂量口灌土霉素的大菱鲆进行连续采样监测。结果表明，土霉素在大菱鲆血液、肌肉、肝脏中药代动力学特征分别符合带时滞的一级吸收二室开放模型、带时滞的一级吸收二室开放模型和带时滞的一级吸收一室开放模型。土霉素在大菱鲆体内消除速度较慢，16℃水温的实验条件下，在大菱鲆肌肉、肝脏中的休药期分别为28天和10天。

Study on Pharmacokinetic and Eliminate of Oxytetracycline in Turbot

Abstract: This article is the first to study on pharmacokinetic and eliminate of OTC in turbot after oral administration. The residue of OTC in turbot which was exposured to 80 mg/kg b.w. OTC solution was monitored continually by HPLC. Pharmacokinetic studies showed that the concentration-time course of the drug conformed to the characteritics of the two compartment open model with the first order absorption and a lagtime for the blood and the muscle, and the one compartment open model with first order absorption and a lagtime for the liver. OTC was slowly eliminated in turbot. The concerntration of OTC in the muscle was below LOD after 28d , and the concerntration of OTC in the liver was below LOD after 10d.