雌二醇对哺乳动物子宫内膜血管生成调控的研究进展

随着畜牧养殖业的发展,雌性动物的妊娠问题已经越来越突出。值得关注的是,在畜牧兽医产科临床上,妊娠过程中动物子宫血管的生成不足会导致胚胎着床困难增加、流产和胎儿停止发育等问题。近年来临床及实验室对肿瘤血管生成的作用及生成机制的研究颇多,因肿瘤血管的生长机制与子宫内血管的生长机制存在一定的类似性。所以,借鉴肿瘤血管生成的相关研究,了解血管生成的作用及血管生成的机制,为后期进一步研究雌二醇对反刍动物子宫内膜血管形成的机制奠定基础。

‘The Regulation by Estradiol on Mammalian Endometrial Angiogenesis: Research Progress

With the development of animal husbandry, the pregnancy problem of female animals has become more and more prominent. It is worth noting that in the clinical practice of animal husbandry and veterinary medicine, insufficient formation of blood vessels in the uterus of animals during pregnancy could increase the difficulty in embryo implantation, miscarriage and fetal development. In recent years, there have been many studies on the role and mechanism of tumor angiogenesis in clinics and laboratories. Since there is a similarity between the growth mechanism of tumor blood vessels and the growth mechanism of blood vessels in the uterus, based on the relevant research of tumor angiogenesis, we studied the role of angiogenesis and the mechanism of angiogenesis. The research could lay a foundation for further exploring the mechanism of estradiol on the formation of endometrial blood vessels in ruminants.