新微生物农药抑霉菌素的研究

抑霉菌素产生菌经形态学特征及生理生化特性等分类学研究 ,定名为刺孢吸水链霉菌天目山亚种。主要活性组分经UV、HNMR、DEPTCNMR及H HCOSY等光谱分析 ,推知其化学结构系一新的核苷类抗生素。采用二倍稀释法对其展开体外抗菌活性研究 ,结果表明抑霉菌素对单丝壳菌、担子菌、圆形刺盘孢等多种农作物真菌病害病原菌具有强生长抑制作用

STUDY ON A NEW ANTIFUNGAL ANTIBIOTIC,YIMEIMYCIN--ISOLATION,STRUCTURE ELUCIDATION AND BIOLOGICAL ACTIVITIES

Strain HA-8416,the producer of yimeimycin, was isolated from a soil sample collected in Hangzhou, Zhejiang province, China. Based on the investigation of morphological, cultural, physiological and biochemical characteristics as well as the cell wall chemical composition, strain HA-8416 is extremely similar to Streptomyces. hygrospinosus SF-104 , and named Streptomyces hygrospinosus var tianmushanensis n.var.Sang et al. By means of spectroscopic analysis (UV, 1H-NMR, DEPT CNMR and H-H COSY) , yimeimycin was identified as a new antibiotic of the nucleoside family. Yimeimycin appeared no activities against G /G-bacteria, but was active against the fungi, Sphaerotheac cucurbitae, Pellicularia sasakii, Colletotrichum orbiculare, especially.