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Enlightened Mannhemia haemolytica lung inflammation in bovinized mice |
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| Authors: | Fabio Franco Stellari Sophia Lavrentiadou Francesca Ruscitti Sarah Jacca Valentina Franceschi Maurizio Civelli Chiara Carnini Gino Villetti Gaetano Donofrio |
| Institution: | 1.Department of Medical Veterinary Science, University of Parma, via del Taglio 10, 43126 Parma, Italy;2.Corporate Pre-clinical R&D, Chiesi Farmaceutici S.p.A, Largo Francesco Belloli 11/A, 43122 Parma, Italy;3.Department of Biomedical Biotechnological and Translational Sciences, University of Parma, via del Taglio 10, 43126 Parma, Italy |
| Abstract: | Polymorphonuclear cells diapedesis has an important contribution to the induced Mannhemia haemolytica (M. haemolytica) infection lung inflammation and IL-8 is the primary polymorphonuclear chemoattractant. Using a bovine IL-8/luciferase transiently transgenized mouse model, the orchestration among M. haemolytica, IL-8 promoter activation and neutrophilia was followed in real time by in vivo image analysis. |
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