| Targeted myostatin loss-of-function mutation increases type Ⅱ muscle fibers in Meishan pigs |
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| 作者姓名： | QIAN Li-li XIE Jing-yi GAO Ting CAI Chun-bo JIANG Sheng-wang BI Han-fang XIE Shan-shan CUI Wen-tao |
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| 作者单位： | 1. Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University;2. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences;3. College of Animal Medicine, China Agricultural University |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (81800215), the Shandong Provincial Natural Science Foundation, China (ZR2017BH032), and the National Transgenic Project of China (2014ZX08006-003, 2016ZX08006-001). |
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| 摘 要： | Myostatin(MSTN) is a negative regulator of skeletal muscle growth and development. The skeletal muscle in MSTN–/–mice is significantly hypertrophied, with muscle fiber type II increasing significantly while muscle fiber type I decreasing.However, it is still not clear how the skeletal muscle types change in MSTN–/– pigs, and how the mechanism for MSTN regulates fiber types, especially in large animals like pigs. This study conducted a comprehensive analysis of the compositi...
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| 收稿时间： | 2020-07-15 |
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