Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts |
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| Authors: | Chiu Po Yee Lam Philip Y Yan Chung Wai Ko Kam Ming |
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| Affiliation: | a Department of Biochemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China |
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| Abstract: | The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging. |
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| Keywords: | Schisandrin B Solar irradiation Photo-aging Oxidative stress Glutathione BJ human fibroblasts |
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