Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells |
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| Authors: | Gao Xiaoping Zhang Guolin Zhou Min Luo Dixiang Li Bogang |
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| Affiliation: | Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu 610041, China. |
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| Abstract: | A dose-dependent and significant (P<0.01) antiproliferative effect of Goldfussia psilostachys ethanolic extract was observed on K562 cells. The IC(50) is ca. 0.5 microg/ml. The extract markedly increases the proportion of cell in G2/M phases and decreases the population of cells in G0/G1 phases. Moreover, the antimitotic effect is correlated with polymerization of microtubule assembly. These results indicate that G. psilostachys ethanolic extract inhibits the proliferation of K562 cells and disrupts the normal dynamic of microtubules during mitosis. |
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| Keywords: | Goldfussia psilostachys Cell growth inhibition Cell cycle Antimitosis Tubulin polymerization K562 cell line |
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