UCPs基因多态性与脂肪代谢的相关性研究

解偶联蛋白(uncoupling protein,UCPs)是线粒体内膜上具有调节质子跨膜转运作用的载体蛋白,在调节动物能量代谢、脂肪沉积及脂肪酸氧化等方面起着重要作用。到目前为止,至少有5种(UCP1、UCP2、UCP3、UCP4和UCP5)这个家族的蛋白质已经在人类、哺乳动物、禽类、鱼甚至在植物的不同组织线粒体的内膜上被发现。UCPs在能量代谢动态平衡中、机体生热作用、肥胖、糖尿病及自由基代谢中起到重要的作用,解偶联蛋白基因已经被列为参与能量代谢和体温调节的候选基因。大量的研究报道了人类UCPs基因突变对脂肪代谢、糖尿病及其并发症、肥胖症的影响。作者从UCP1、UCP2及UCP3基因的定位、结构、分布、基因的多态突变与脂肪代谢、糖尿病及肥胖症之间的相关性研究进行了综述。

The Polymorphisms of UCPs Genes Associated with Fat Metabolism

Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport, hence generating heat rather than energy. In mammals， more than five family members have been identified including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5),and UCP5.The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity， diabetes and considered candidate genes for obesity and insulin resistance.Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport, hence generating heat rather than energy. In mammals,more than five family members have been identified including UCP1,they have been as important potential targets for treatment of aging,degenerative diseases,diabetes,and obesity in clinical. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolismobesity, and diabetes.This review summarizes data supporting the roles of UCP1, UCP2 and UCP3 in energy dissipation,and the genetic variety association with the fat metabolism,obesity and diabetes in humans.