10%磷酸替米考星可溶性粉在靶动物鸡的安全性试验

为评价10%磷酸替米考星可溶性粉对靶动物鸡的安全性，本试验选择40只25日龄健康白羽杂交肉鸡，随机分为4组，每组10只，公母各半。各组分别以0（0 mg/L）、1（75 mg/L，以替米考星计）、3（225 mg/L，以替米考星计）和5（375 mg/L，以替米考星计）倍推荐剂量的10%磷酸替米考星可溶性粉混饮给药，连用9 d。试验期间观察鸡的临床表现、体重变化和饲料消耗，试验结束后进行病理学检查，并测定血液生理指标和血清相关生化指标的变化。结果显示，10%磷酸替米考星可溶性粉在本试验条件下以5倍以下剂量饮水给药对鸡的生长性能无显著影响（P>0.05），在血液生理指标及血清生化指标方面，不具有剂量依赖性的显著变化（P>0.05）。该试验结果表明，10%磷酸替米考星可溶性粉按推荐剂量（75 mg/L）饮水给药对靶动物鸡具有较大的安全性。

Target Animal Safety Test of 10% Phosphoric Acid Tilmicosin Soluble Powder in Chickens

In order to evalutate the safety of 10% phosphoric acid tilmicosin soluble powder on chickens. Forty healthy White-feathered hybrid chickens (20♂+20♀) at the age of 25 days were divided into 4 groups randomly. Each group was given tilmicosin with water at dosage of 0 mg/L,recommended dosage (75 mg/L),3 times of recommended dosage (225 mg/L) and 5 times of recommended dosage (375 mg/L) for 9d continuously. During the experiment, clinical feature,weight change and food consumption were observed,and when this experiment was ended, general pathology examination,clinical hematologic studies,blood biochemical indexes examination and physiological parameters examination were undertaken. The results showed that there were no significant influence on growth performance of chicken at the maximum dosage of 5 times of recommended dosage for 9d continuously (P>0.05), and there were no dose-dependent significant changes in physiological parameters and blood biochemical indexes. The conclusion revealed that it was very safe for chickens to use 10% phosphoric acid tilmicosin soluble powder at recommended dosage (75 mg/L).