| G蛋白偶联受体120在动物脂代谢及免疫调节中作用的研究进展 |
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| 引用本文： | 申青怡,杨晓静.G蛋白偶联受体120在动物脂代谢及免疫调节中作用的研究进展[J].畜牧与兽医,2021(2):132-136. |
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| 作者姓名： | 申青怡 杨晓静 |
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| 作者单位： | 南京农业大学动物医学院 |
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| 基金项目： | 国家自然科学基金项目(31772696)。 |
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| 摘 要： | 脂肪酸在动物脂质代谢和免疫调节中起着至关重要的作用,G蛋白偶联受体120(G-protein coupled receptor 120,GPR120)又被称为游离脂肪酸受体4(free fatty acid receptor 4,FFAR4)是G蛋白偶联受体家族成员。它可以被长链脂肪酸激活,参与调节机体糖脂代谢,是治疗人及畜禽脂质代谢紊乱及免疫调节等相关疾病的热点靶点。本文就近来GPR120在脂肪组织中的研究现状、对免疫调节的作用及其激动剂或配体作为药物运用的可能做一综述。
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| 关 键 词： | 脂肪组织 G蛋白偶联受体120 脂代谢 免疫调节 激动剂 |
Progress in research on the role of GPR120 in animal lipid metabolism and immune regulation |
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| SHEN Qingyi,YANG Xiaojing.Progress in research on the role of GPR120 in animal lipid metabolism and immune regulation[J].Animal Husbandry & Veterinary Medicine,2021(2):132-136. |
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| Authors: | SHEN Qingyi YANG Xiaojing |
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| Institution: | (College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | Fatty acid metabolism plays a vital role in the development of animal lipid metabolism and immune regulation. G-protein coupled receptor 120(GPR120) is also known as free fatty acid receptor 4(FFAR4), and it is a new member of the G protein-coupled receptor family. It can be activated by long-chain fatty acids and it participates in regulating glucose and lipid metabolism in the body. And it is a hot target for treating diseases related with lipid metabolism and immune regulation in humans and livestock. This paper reviews the status of recent researches on the functions of GPR120 in adipose tissue and immune regulation, and the possible medical use of its agonists or ligands. |
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| Keywords: | adipose tissue G-protein coupled receptor 120 lipid metabolism immune regulation agonist |
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