Metacaspase在酵母凋亡过程中的作用 |
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引用本文: | 卢丽,冯霞,徐婷婷,李树峰,佟慧丽,严云勤.Metacaspase在酵母凋亡过程中的作用[J].现代农业科技,2010(8):36-38,40. |
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作者姓名: | 卢丽 冯霞 徐婷婷 李树峰 佟慧丽 严云勤 |
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作者单位: | 东北农业大学生命科学学院,黑龙江哈尔滨,150030 |
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摘 要: | Metacaspase是由YCA1/MCA1编码的一种哺乳动物caspases同系物。由于其分子结构的差异,使其断裂为不同的特异性底物。在哺乳动物中,凋亡被一组蛋白酶caspases定向激活,断裂特异性底物且触发细胞死亡。环境损伤、细胞内缺陷、预凋亡基因的异源表达诱导具有典型凋亡特征的酵母细胞死亡与metacaspase紧密相关。删除metacaspase可以阻碍不同因素引起的死亡,metacaspase在酵母细胞凋亡中具有核心作用。
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关 键 词: | 酵母 YCA1 凋亡 |
Role of Metacaspase in Yeast Apoptisis Progress |
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Authors: | LU Li FENG Xia XU Ting-ting LI Shu-feng TONG Hui-li YAN Yun-qin |
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Institution: | LU Li FENG Xia XU Ting-ting LI Shu-feng TONG Hui-li YAN Yun-qin(College of Life Science,Northeast Agricultural University,Harbin Heilongjiang 150030) |
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Abstract: | Metacaspase is a kind of mammal caspases homolog which coded by the YCA1/MCA1 gene.It can break into different specificity substrates because its difference in molecular structure.In mammals,apoptosis can be activated directly by a group of proteases,called caspases,then cleave specific substrates and trigger cell death.Damaging environment,certain intracellular defects and heterologous expression of pro-apoptotic genes inducing death in yeast cells exhibiting typical markers of apoptosis was closely relate... |
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Keywords: | YCA1 |
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