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| 大肠埃希菌多重耐药调节子研究进展 | |
| 引用本文： | 李娟,佟海山,赵泳波,李乾学,邓旭明.大肠埃希菌多重耐药调节子研究进展[J].动物医学进展,2006,27(7):42-45. |
| 作者姓名： | 李娟 佟海山 赵泳波 李乾学 邓旭明 |
| 作者单位： | 1. 黑龙江八一农垦大学食品学院,黑龙江大庆,163319 2. 吉林大学畜牧兽医学院,吉林长春,130062 3. 黑龙江齐齐哈尔医学院,黑龙江齐齐哈尔,161042 4. 军事医学科学院军事兽医研究所,吉林长春,130062 |
| 摘 要： | 大肠埃希菌多重抗生素耐药主要是由多重耐药调节基因和外输泵共同作用产生的。大肠埃希菌多重耐药调节子是广泛存在于肠杆菌科细菌染色体上的抗生素多重耐药调节中心,是大肠埃希菌耐药的主要组成部分。为解决多重抗生素耐药问题,很多专家和学者对大肠埃希菌多重耐药调节子和外输泵的耐药机制进行了深入的研究,研究开发多重抗生素耐药基因消除剂和外输泵抑制剂,或增加外输泵抑制基因的表达,将成为从根本上解决多重抗生素耐药问题的最好方法。文章对大肠埃希菌AcrAB、AcrAB-Tolc,Mar和膜孔蛋白Ompf、Ompc等多重抗生素耐药调节子的组成、功能及其影响因素进行了综述。 |
| 关 键 词： | 大肠埃希菌 多重耐药调节子 功能 影响因素 |
| 文章编号： | 1007-5038（2006）07-0042-04 |
| 收稿时间： | 2005-12-20 |
| 修稿时间： | 2005年12月20 |
Progress on Multiple-Antibiotic-Resistance Regulon of Escherichia coli |
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| LI Juan,TONG Hai-shan,ZHAO Yong-bo,LI Qian-xue,DENG Xu-ming.Progress on Multiple-Antibiotic-Resistance Regulon of Escherichia coli[J].Progress In Veterinary Medicine,2006,27(7):42-45. | |
| Authors: | LI Juan TONG Hai-shan ZHAO Yong-bo LI Qian-xue DENG Xu-ming |
| Institution: | 1. College of Food Science, Heilongj iang August First Land Reclamation University, Daqing , Heilongj iang , 163319, China t 2. College of Animal Science and Veterinary Medicine,Jilin University ,Changchun,Jilin, 130062, China; 3. Qiqihar Medicial College of Heilongjiang , Qiqihar , Heilongjiang, 161042, China; 4. The Military Veterinary Institute, Military Academy of Medical Sciences, Changch un, Jilin, 130062, China |
| Abstract: | Multiple-antibiotic resistance of Escherichia coli is caused by both multiple-antibiotic-resistance regulon and efflux pump.Multiple-antibiotic-resistance regulon is the main factor of Escherichia coli resistance,which commonly exists in the chromosome of the multiple-antibiotic-resistance regular center of antibiotics in the genes of enteric bacilli genes.Nowadays,more and more experts and scholars are engaged in the further study of the mechanism of multiple-antibiotic-resistance regulon and efflux pump in Escherichia coli to solve the multiple-antibiotic resistance.The best way is to develop multiple-antibiotic-resistance regulon counteractant and efflux pump inhibitor,or to increase the expression of efflux pump.This review discribed the construction and function,as well as the affected factors of multipleantibiotic-resistance regulon such as AcrAB and Mar,Ompf and Ompc porin in Escherichia coli. |
| Keywords: | Escherichia coli multiple-antibiotic-resistance regulon construction function affected factors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |