| 蛋白质结构的预测及其应用 |
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| 引用本文： | 宁正元,林世强.蛋白质结构的预测及其应用[J].福建农林大学学报(自然科学版),2006,35(3):308-313. |
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| 作者姓名： | 宁正元 林世强 |
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| 作者单位： | 福建农林大学计算机与信息学院,福建,福州,350002 |
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| 摘 要： | 蛋白质结构的预测是结构基因组学的重要研究内容,本文就蛋白质结构预测的方法和应用进行了综述,介绍了比较建模、折叠识别、从头计算等3种方法及其在结构基因组学研究、药物设计、蛋白质设计中的应用,并且对蛋白质结构预测存在的主要问题进行了讨论,指出了今后蛋白质结构预测研究重点在于优化比对算法和计分函数以及膜蛋白的结构预测.
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| 关 键 词： | 蛋白质结构 比较建模 折叠识别 从头计算 |
| 文章编号： | 1671-5470(2006)03-0308-06 |
| 收稿时间： | 2006-03-13 |
| 修稿时间： | 2006-04-20 |
Protein structure prediction and its application |
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| NING Zheng-yuan,LIN Shi-qiang.Protein structure prediction and its application[J].Journal of Fujian Agricultural and Forestry University,2006,35(3):308-313. |
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| Authors: | NING Zheng-yuan LIN Shi-qiang |
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| Institution: | College of Computer and Information, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China |
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| Abstract: | Protein structure prediction is an important part of structural genomics research.This review summarized the methods and applications of protein structure prediction.Methods of comparative modeling,fold recognition and ab inito prediction and their applications in structural genomics research,drug design and protein design were elaborated.The main problems of protein prediction research were discussed.It was proposed that the future research emphasis in this field included optimizing alignment algorithm and scoring function and the research on membrane protein prediction. |
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| Keywords: | protein structure comparative modeling fold recognition ab initio prediction |
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