Baited vaccines: A strategy to mitigate rodent‐borne viral zoonoses in humans |
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| Authors: | Emelissa J Mendoza Bryce Warner Gary Kobinger Nicholas H Ogden David Safronetz |
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| Institution: | 1. Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada;2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada;3. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;4. Centre Hospitalier de l’Université Laval, Quebec City, Quebec, Canada;5. Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, St‐Hyacinthe, Quebec, Canada |
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| Abstract: | Rodents serve as the natural reservoir and vector for a variety of pathogens, some of which are responsible for severe and life‐threatening disease in humans. Despite the significant impact in humans many of these viruses, including Old and New World hantaviruses as well as Arenaviruses, most have no specific vaccine or therapeutic to treat or prevent human infection. The recent success of wildlife vaccines to mitigate rabies in animal populations offers interesting insight into the use of similar strategies for other zoonotic agents of human disease. In this review, we discuss the notion of using baited vaccines as a means to interrupt the transmission of viral pathogens between rodent reservoirs and to susceptible human hosts. |
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| Keywords: | emerging infectious diseases hantavirus Lassa virus wildlife vaccines zoonotic diseases |
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