| 高热清口服液制备工艺研究 |
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| 引用本文： | 林红,李成应,黄娟,郑莉,邢妍美,吴连勇.高热清口服液制备工艺研究[J].中兽医医药杂志,2010,29(2):35-37. |
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| 作者姓名： | 林红 李成应 黄娟 郑莉 邢妍美 吴连勇 |
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| 作者单位： | 齐鲁动物保健品有限公司,山东济南,250100 |
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| 摘 要： | 目的:优化高热清口服液的制备工艺。方法:采用正交设计法研究水提取的最佳条件,比较3种醇沉浓度(50%、60%、75%)对高热清口服液中黄芩苷含量的影响;采用高效液相色谱(HPLC)法测定黄芩苷的含量。结果:以10倍量水,浸泡0.5h,提取3次,每次提取1.5h时,水提液中黄芩苷含量最高;3种醇沉浓度的黄芩苷含量无显著性差异(P0.05),以50%醇沉浓度时成本最低。根据最佳工艺路线制备高热清口服液,3批成品的黄芩苷含量无显著性差异(P0.05),薄层鉴别与pH值检查均符合质量标准规定。结论:采用正交试验设计以黄芩苷的含量做为评价指标,是筛选其不同制备工艺的有效方法。按照最佳工艺路线制备的高热清口服液成品质量可控、稳定性良好。
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| 关 键 词： | 高热清 口服液 黄芩苷 高效液相色谱 |
Optimization on the preparing process for Gaoreqing oral liquid |
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| LIN Hong,LI Cheng-ying,HUANG Juan,ZHENG Li,XING Yan-mei,WU Lian-yong.Optimization on the preparing process for Gaoreqing oral liquid[J].Journal of Traditional Chinese Veterinary Medicine,2010,29(2):35-37. |
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| Authors: | LIN Hong LI Cheng-ying HUANG Juan ZHENG Li XING Yan-mei WU Lian-yong |
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| Institution: | LIN Hong,LI Cheng-ying,HUANG Juan,ZHENG Li,XING Yan-mei,WU Lian-yong (Qilu Animal Health Products Co.Ltd.,Ji\'nan Sh,ong 250100,China) |
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| Abstract: | Objective:To optimize the preparaing process for Gaoreqing oral liquid. Methods: The water extraction process was optimized by orthogonal design. The effects of 3 ethanol sedimentation concentrations(50%, 60% and 75%)on the yield of Baicalin were compared. The contents of Baicalin was determined by high-performance liquid chromatography. Results:The maximum content of Baicalin was obtained by adding 10 times volume of water, soaking 0.5 hour and extracting thrice(1.5 hours each time). The yields of Baicalin... |
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| Keywords: | Gaoreqing oral liquid Baicalin high-performance liquid chromatography |
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