鼻咽癌前病变证候、证素、证型调查表的研制及评价

目的 探索鼻咽癌前病变规范化的四诊信息采集方案，并以此为基础建立鼻咽癌前病变四诊信息采集的相关标准。方法 在文献调查研究、专家组讨论基础上，筛选出与鼻咽癌前病变相关的证候、证素及证型，然后参照国际通用调查表的设计，研制出鼻咽癌前病变证候、证素、证型调查表，并对该表的信度和效度进行检测。结果 研制出了鼻咽癌前病变证候、证素、证型调查表，对其信度和效度进行了检验，结果显示：调查表具备良好的内部一致性信度和重测信度，内容符合中医理论及临床实际，具备较好的真实性和可靠性。结论 鼻咽癌前病变证候、证素、证型调查表具备较好的信度与效度，基本达到鼻咽癌前病变中医四诊信息采集规范化的目的。在规范采集四诊信息的基础上，再结合运用证素计量辨证法，应能有效提升中医药防治鼻咽癌前病变的整体水平。

Development and Evaluation of a Questionnaire on Syndromes, Syndrome Elements and Syndrome Types of Nasopharyngeal Precancerous Lesion

Objective To develop a standardized plan for information collection of four diagnostic methods in terms of nasopharyngeal precancerous lesion (NPL), base on which to establish a relative standard for information collection of four diagnostic methods of NPL. Methods Syndromes, syndrome elements and syndrome types related to NPL were screened out on the basis of literature survey and expert discussion. Then, a questionnaire on syndromes, syndrome elements and syndrome types of NPL was developed according to the design of international questionnaires. At last, the reliability and validity of such a questionnaire were evaluated. Results After the questionnaire on syndromes, syndrome elements and syndrome types of NPL was established, there were good reliability of internal consistency and retest reliability as shown from the results of reliability and validity evaluation on such a questionnaire, and it had authenticity and reliability. Conclusion This questionnaire holds good reliability and validity in surveying the syndromes, syndrome elements and syndrome types of NPL, and reaches the standardized level for information collection of four diagnostic methods of NPL. Therefore, such a questionnaire can be effectively used to improve the overall level of prevention and treatment in NPL, when combined with syndrome differentiation method of syndrome element measurement on the basis of standardized information collection of four diagnostic methods.