Pharmacokinetic indices for cefovecin after single‐dose administration to adult sea otters (Enhydra lutris) |
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| Authors: | E A Lee B A Byrne M A Young M Murray M A Miller L A Tell |
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| Institution: | 1. Departments of Medicine and Epidemiology, University of California, Davis, CA, USA;2. Department of Pathology, Microbiology and Immunology, University of California, Davis, CA, USA;3. Monterey Bay Aquarium, Monterey, CA, USA;4. Department of Fish and Wildlife, Office of Spill Prevention and Response, Marine Wildlife Veterinary Care and Research Center California, Santa Cruz, CA, USA |
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| Abstract: | Seven sea otters received a single subcutaneous dose of cefovecin at 8 mg/kg body weight. Plasma samples were collected at predetermined time points and assayed for total cefovecin concentrations using ultra‐performance liquid chromatography and tandem mass spectrometry. The mean (±SD) noncompartmental pharmacokinetic indices were as follows: CMax (obs) 70.6 ± 14.6 μg/mL, TMax (obs) 2.9 ± 1.5 h, elimination rate constant (kel) 0.017 ± 0.002/h, elimination half‐life (t1/2kel) 41.6 ± 4.7 h, area under the plasma concentration‐vs.‐time curve to last sample (AUClast) 3438.7 ± 437.7 h·μg/mL and AUC extrapolated to infinity (AUC0→∞) 3447.8 ± 439.0 h·μg/mL. The minimum inhibitory concentrations (MIC) for select isolates were determined and used to suggest possible dosing intervals of 10 days, 5 days, and 2.5 days for gram‐positive, gram‐negative, and Vibrio parahaemolyticus bacterial species, respectively. This study found a single subcutaneous dose of cefovecin sodium in sea otters to be clinically safe and a viable option for long‐acting antimicrobial therapy. |
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