| 鼠伤寒沙门氏菌对鼠淋巴细胞MHC－1、MHC－2、ICAM－1和CD4表达的影响 |
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| 引用本文： | 马学恩.鼠伤寒沙门氏菌对鼠淋巴细胞MHC－1、MHC－2、ICAM－1和CD4表达的影响[J].中国兽医学报,1995(3). |
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| 作者姓名： | 马学恩 |
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| 作者单位： | 内蒙古农牧学院动物医学系 |
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| 摘 要： | 应用流式细胞仪技术，检测经口灌服１０３个鼠伤寒沙门氏菌（Ｓａｌｍｏｎｅｌｌａｔｙｐｈｉｍｕｒｉｕｍ），４８ｈ后迫杀的Ｃ５７Ｂ１６／Ｈ２ｂ鼠外周淋巴结、肠系膜淋巴结、脾和外周血中淋巴细胞ＭＨＣ－１、ＭＨＣ－２、ＩＣＡＭ－１和ＣＤ４４种受体的变化。结果表明，鼠伤寒沙门氏菌使外周血淋巴细胞ＭＨＣ－１、ＭＨＣ－２和ＩＣＡＭ－１的表达显著升高（Ｐ＜０．００１），肠系膜淋巴结中淋巴细胞ＭＨＣ－２、ＣＤ４和外周血淋巴细胞ＣＤ４的表达也有升高。
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| 关 键 词： | 鼠伤寒沙门氏菌，淋巴细胞，受体表达，流式细胞仪 |
Effects of Salmonella typhimurium on the Expression of MHC-1,MHC-2,ICAM-1 and CD4 of Lymphocytes in Mice |
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| Ma Xueen.Effects of Salmonella typhimurium on the Expression of MHC-1,MHC-2,ICAM-1 and CD4 of Lymphocytes in Mice[J].Chinese Journal of Veterinary Science,1995(3). |
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| Authors: | Ma Xueen |
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| Abstract: | C57B16/H2b mice were administered orally 103 Salmonella typhimuriumand killd 48 h after challenge. The effects of S.typhimurium on the expression of MHC-1, MHC-2,ICAM-1 and CD4 of the lymphocytes in peripheral blood (PBL),peripherallymphonode(PLNL) ,mesenteric lymphonode(MLNL), and spleen (PL)were investi-gated using flow cytometry. Among the lymphocyte receptors tested the expression ofMHC-1, MHC-2 and ICAM-1 on PBL were upraised significantly(P<0. 001). The ex-pression of MHC-2,CD4 on MLNL and CD4 on PBL were also enhanced. |
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| Keywords: | Salmonella typhimurium lympocyte receptor expression flow cytometry |
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