Plasma and Tissue Levels of Trimethoprim in The Rainbow Trout,Salmo Gairdneri,After Absorption From Fresh and Salt Water |
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Authors: | Torill Bergsj Erling Sgnen |
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Institution: | Department of Pharmacology and Toxicology, Veterinary College of Norway, Oslo, Norway |
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Abstract: | This is a comparative study of uptake of trimethoprim from 1) fresh water, 2) salt water after 7 days of adaption and 3) salt water without previous adaptation. The rate and extent of absorption were found to vary significantly. The salt water adapted group reached a plasma concentration of approx. 1 µg/ml after 10 h, the unadapted salt water group after 24 to 48 h and the fresh water group did not reach this concentration. The results are discussed in relation to the non-ionic diffusion theory and to the alterations taking place in euryhaline species of fish during adaptation to salt water. |
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Keywords: | trimethoprim rainbow trout Salmo gairdneri absorption fresh water salt water |
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