| 5-(2-乙基亚环己基)-2-取代氨基咪唑啉酮类化合物的合成及其杀菌活性 |
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| 引用本文： | 雷建平,董宏波,汤博,王明安.5-(2-乙基亚环己基)-2-取代氨基咪唑啉酮类化合物的合成及其杀菌活性[J].农药学学报,2012,14(6):669-672. |
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| 作者姓名： | 雷建平 董宏波 汤博 王明安 |
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| 作者单位： | 1.中国农业大学 应用化学系,北京 100193 |
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| 基金项目： | "十二五"国家科技支撑计划(2011BAE06B04);国家自然科学基金(21172254)资助项目. |
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| 摘 要： | 以2-乙基环己酮和2-硫代乙内酰脲为起始原料,经Knoevenagel缩合反应制得5-(2-乙基亚环己基)-2-硫代咪唑啉-4-酮(1),化合物1在乙醇钠-乙醇体系中与碘甲烷反应得到5-(2-乙基亚环己基)-2-甲硫基咪唑啉-4-酮(2),化合物2再与相应的取代苄胺在冰醋酸体系中回流制得新化合物3a～3f,其化学结构均经1H NMR、IR和MS确证。初步生物活性测定结果表明:在50 μg/mL下,部分目标化合物对油菜菌核病菌Sclerotinia scleotiorum显示出良好的抑制活性,其中3a、3c、3e和3f的EC50值分别为12.10、8.73、10.11和7.67 μg/mL。
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| 关 键 词： | 2-氨基咪唑啉-4-酮 2-硫代乙内酰脲 合成 杀菌活性 |
| 收稿时间： | 2012/7/30 0:00:00 |
| 修稿时间： | 9/6/2012 12:00:00 AM |
Synthesis and fungicidal activity of 5-(2-ethylcyclohexylidene)-2-aminoimidazolin-4-one derivatives |
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| LEI Jianping,DONG Hongbo,TANG Bo and WANG Ming''an.Synthesis and fungicidal activity of 5-(2-ethylcyclohexylidene)-2-aminoimidazolin-4-one derivatives[J].Chinese Journal of Pesticide Science,2012,14(6):669-672. |
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| Authors: | LEI Jianping DONG Hongbo TANG Bo and WANG Ming'an |
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| Institution: | 1.Department of Applied Chemistry, China Agricultural University, Beijing 100193, China |
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| Abstract: | A series of new 5-(2-ethylcyclohexylidene)-2-aminoimidazolin-4-one derivatives 3a-3f were synthesized via Knoevenagel condensation,methylation and substitution reaction using 2-ethylcyclohexanone and 2-thiohydantoin as starting material.Their structures were confirmed by 1H NMR,IR and MS spectral data.The preliminary bioassay showed that some of the compounds have good fungicidal activity against Sclerotinia scleotiorum at the concentration of 50 μg/mL.The EC50 values of compound 3a,3c,3e and 3f against S.scleotiorum were 12.10,8.73,10.11 and 7.67 μg/mL, respectively. |
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| Keywords: | 2-aminoimidazolin-4-one 2-thiohydantoin synthesis fungicidal activity |
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