鸡贫血病灭活疫苗免疫后雏鸡免疫状况研究

应用鸡传染性贫血病灭活疫苗免疫雏鸡后，１０、２０、３５、４５天检测了空白对照组、免疫组的外周血液、胸腺、脾脏和法氏囊内ＣＤ３＋、ＣＤ４＋、ＣＤ８＋、γδＴ细胞亚群、ＩｇＧ阳性细胞的变化；并且在３５天、４５天检测免疫攻毒组和攻毒组上述细胞免疫和体液免疫指标的变化。结果显示，应用贫血病灭活疫苗后免疫组雏鸡的Ｔ细胞亚群的ＣＤ４／ＣＤ８比值出现明显降低，ＩｇＧ阳性细胞有升高变化；免疫攻毒组雏鸡状态明显好于攻毒组。研究表明，鸡传染性贫血病疫苗可以激发机体体液免疫反应，并在一定程度上诱导ＣＴＬ活化，对ＣＡＶ攻击产生足够的免疫保护。

Evaluation in Chickens Inactivated Vaccinated Against Chicken Anemia Virus

The changes of CD3 , CD4 , CD8 , lymphocytes and IgG positive cells in peripheral blood,thymus,spleen and bursa in control and vaccinated groups were measured 10,20,35,45 days, and in vaccinated group and infected group were measured 35 and 45 days past vaccinated with CIA,respectively. The results demonstrated that ratio CD4/CD8 reduced obviously and the number of IgG positive cells raised. The state of chickens in vaccinated group were better than in infected group. The researches showed thatthe CIA vaccine can induced nu- moral immunity respose and activeted CTL, so it can keep chickens safe with CAV infected.