氧化苦参碱治疗慢性乙型肝炎后肝纤维化的疗效观察

目的:观察氧化苦参碱治疗慢性乙型肝炎肝纤维化的疗效。方法:43例慢性乙型肝炎随机分为治疗组22例与对照组21例,治疗组采用氧化苦参碱与常规药物联合治疗,对照组仅采用常规药物治疗。疗程24周。用酶联免疫法测定HBeAg,聚合酶链免疫护增法测定HBV-DNA,用放射免疫法测定治疗前后血清透明质酸(HA)、层黏连蛋白(LN)、IV型胶原(CIV)、III型前胶原(PCIII)水平。结果:治疗组HBeAg转阴率36.4%(8/22),HBV-DNA转阴率54.5%(12/22)。血清HA、LN、CIV及PCIII明显降低(P<0.01)。结论:氧化苦参碱有较好的抗乙型肝炎肝纤维化作用。

Observations on Theraputic Effect of Oxymatrine on Liver Fibrosis Resulted from Chronic Hepatitis B

Objective: To observe the efficacy of Oxymatrine in treating of patients with fibrosis of hepatitis B.Methods: 43 patients with chronic hepatitis B were randomly divided into the treated group(22 cases) and the control group(21 cases),Patients in both groups received conventional drugs for 24 weeks,however,Patients in treated group also received Oxymatrine 600mg per oral daily for 24 weeks.HBeAg in ELISA and HBV-DNA with PCR were measured,Serum HA,LN,CIV and PCIII were measured in the above patients by radiommunoassay at 0,24 weeks treatment.Results: HBeAg of 8 in 22 cases(36.4%) of the treated group converted to negative,and HBV-DNA of 12 in 22 cases(54.5%) of the treated group converted to nagative.The serum levels of HA,LN,CIV and PCIII were decreased in the treated group,but there were no change during the period in the control group.There was significant difference between the two groups.Conclusion: Oxymatrine combined with conventional drugs is effective in treatment of fibrosis of chronic hepatitis B.