Marine Indole Alkaloids |
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Authors: | Natalie Netz Till Opatz |
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Institution: | Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany; E-Mail: |
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Abstract: | Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed. |
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Keywords: | indoles alkaloids marine natural products bisindoles nitrogen heterocycles carbolines prenylated indoles diketopiperazines |
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