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| TGF-系统及其在硬骨鱼中的研究进展 | |
| 引用本文： | 詹绪良, 吴金英, 李文笙. TGF-系统及其在硬骨鱼中的研究进展[J]. 南方水产科学, 2013, 9(3): 90-96. DOI: 10.3969/j.issn.2095-0780.2013.03.015 |
| 作者姓名： | 詹绪良 吴金英 李文笙 |
| 作者单位： | 1.中山大学生命科学学院水生经济动物研究所，广东省水生经济动物良种繁育重点实验室，广东 广州 510275 |
| 基金项目： | 现代农业产业技术体系（罗非鱼体系）专项资金（CARS-49）；公益性行业（农业）科研专项(3-49-10)； |
| 摘 要： | TGF-（transforming growth factor-）是一类多效应细胞因子，在很多生理活动中发挥功能。TGF-以前体形式合成，随后被切割活化形成成熟的TGF-。TGF-以二聚体的形式发挥作用，与受体TRI（transforming growth factor- receptor I）和TRII（transforming growth factor- receptor Ⅱ）形成一个大型复合物后，磷酸化胞内的Smad，激活下游信号通路。鱼类中，对TGF-家族成员的研究主要集中在对TGF-1的研究，包括TGF-1与免疫相关和与生殖相关的功能，也有研究表明TGF-1与肝功能相关。此外，有少量对TGF-家族其他成员和TGF-受体的研究。 |
| 关 键 词： | TGF- TGF-受体 硬骨鱼 |
| 收稿时间： | 2012-12-09 |
| 修稿时间： | 2013-01-14 |
TGF- system and its research advances in teleost |
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| ZHAN Xuliang, WU Jinying, LI Wensheng. TGF- system and its research advances in teleost[J]. South China Fisheries Science, 2013, 9(3): 90-96. DOI: 10.3969/j.issn.2095-0780.2013.03.015 | |
| Authors: | ZHAN Xuliang WU Jinying LI Wensheng |
| Affiliation: | 1.Guangdong Provincial Key Lab. for Aquatic Economic Animals; Institute of Aquatic Economic Animals School of Life Sciences, Sun Yat-sen University, Guangzhou 510275，China |
| Abstract: | Transforming growth factor- (TGF-) family members are multi-functional cytokines, which play pivotal roles in many physiological activities. TGF- is synthesized as a pro-TGF- precursor. Subsequently, the N-terminus of the immature protein is removed, and the new proteins form a homodimer. TGF- mediates its biological functions via binding to receptors TRI and TRII, and then phosphorylates intracellular Smad proteins to activate signal pathway. Till now, most researches in TGF- family are focused on TGF-1, which is involved in immune, reproductive and liver functions, while just few studies about the other members of TGF- and TGF- receptors exist. |
| Keywords: | TGF- TGF- receptor teleost |
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