Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32 |
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| Authors: | Ya-Qin Fan Pei-Hai Li Ya-Xi Chao Hao Chen Ning Du Qiu-Xia He Ke-Chun Liu |
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| Affiliation: | 1.Key Lab of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China; E-Mails: (Y.-Q.F.); (P.-H.L.); (Y.-X.C.); (N.D.);2.Institute of Biology, Shandong Academy of Sciences; Research and Development Platform for Drug Screening of Shandong Academy of Sciences, Jinan 250014, China; E-Mails: (Q.-X.H.); (K.-C.L.) |
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| Abstract: | Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5–7, and 9–12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher’s and Marfey’s methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4–6 and 8–12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds. |
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| Keywords: | marine-derived fungus Penicillium expansum secondary metabolites alkaloids cardiovascular effects |
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