Asymmetric T lymphocyte division in the initiation of adaptive immune responses |
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| Authors: | Chang John T Palanivel Vikram R Kinjyo Ichiko Schambach Felix Intlekofer Andrew M Banerjee Arnob Longworth Sarah A Vinup Kristine E Mrass Paul Oliaro Jane Killeen Nigel Orange Jordan S Russell Sarah M Weninger Wolfgang Reiner Steven L |
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| Institution: | Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
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| Abstract: | A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. |
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