| 禽流感病毒的宿主特异性和致病性分子基础 |
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| 引用本文： | 王新卫,詹爱军. 禽流感病毒的宿主特异性和致病性分子基础[J]. 长江大学学报, 2006, 0(2) |
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| 作者姓名： | 王新卫 詹爱军 |
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| 作者单位： | 河南农业大学牧医工程学院，华南农业大学动物科学学院 河南郑州450002，华南农业大学动物科学学院广东广州510642，广东广州510642 |
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| 基金项目： | 广东省科技攻关计划资助项目(A20403) |
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| 摘 要： | 禽流感病毒可感染许多鸟类和哺乳动物,但是其自然宿主范围通常限于野生水禽,如野鸭、海鸥等。近年来出现新的特征,可以感染人类、猫、虎等动物,突破了宿主限制性,出现种间传播。这与其宿主特异性变化和致病力变异有关。为此,依据禽流感病毒的致病特性、抗原蛋白(血凝素蛋白HA)特性和宿主细胞受体特点,结合其它影响因素,阐述了流感病毒的宿主特异性和致病性分子基础,以进一步认识禽流感病毒。
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| 关 键 词： | 流感病毒 宿主 特异性 致病性 分子基础 |
Molecular Base of Host Speciality and Pathogenicity of Avian Influenza Virus |
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| WANG Xin-wei College of Animal Husbandry and Veterinary,Henan Agricultural University,Zhengzhou,Henan ,China,College of Animal Science,South China Agricultural University,Guangzhou,Guangdong ,ChinaZHAN Ai-jun. Molecular Base of Host Speciality and Pathogenicity of Avian Influenza Virus[J]. Journal of Yangtze University, 2006, 0(2) |
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| Authors: | WANG Xin-wei College of Animal Husbandry Veterinary Henan Agricultural University Zhengzhou Henan China College of Animal Science South China Agricultural University Guangzhou Guangdong ChinaZHAN Ai-jun |
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| Affiliation: | WANG Xin-wei College of Animal Husbandry and Veterinary,Henan Agricultural University,Zhengzhou,Henan 450002,China,College of Animal Science,South China Agricultural University,Guangzhou,Guangdong 510642,ChinaZHAN Ai-jun |
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| Abstract: | Avian influenza virus can cause serious disease in a wide variety of birds and mammals,but generally its natural host range is limited to wild ducks and gulls.In recent years new property of avian influenza virus appeared.Human,tiger and cat could be infected by the virus.Host restriction was broken through and interspecies transmission came forth.This is associated with variation of host-range and virulence.Therefore,in order to understand it further,molecular base of both host speciality and pathogenicity of the virus were expatiated on,according to pathogenic characteristics,traits of antigenic protein(Hemagglutinin,HA) of avian influenza virus and property of host cell,togther with other influencing factors. |
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| Keywords: | avian influenza virus host speciality pathogenicity molecular base |
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