鱼类白细胞介素1β基因的研究概况 |
| |
引用本文: | 邱丽华.鱼类白细胞介素1β基因的研究概况[J].水产学报,2005,29(1):115-119. |
| |
作者姓名: | 邱丽华 |
| |
作者单位: | 中国科学院海洋研究所实验海洋生物学开放实验室,山东,青岛,266071;中国水产科学研究院南海水产研究所,广东,广州,510300;中国水产科学研究院南海水产研究所,广东,广州,510300 |
| |
基金项目: | 国家863高技术研究发展计划(2001AA628180);广东省科技计划项目(2003C20313);农业部河口与渔业开放基金项目 |
| |
摘 要: | Interleukin-1β(IL-1β) is one of the most pleiotropic cytokines and a central regulator of the immune and inflammatory responses. Interleukin-1β was initially discovered within mice and humans and over the last 10 years has been characterized within a wide variety of animals. The IL-1β plays a key role in the inflammatory process, enhancing cell-mediated immunity by inducing the growth and proliferation of lymphocytes, connective tissue cells, and by stimulating immune and inflammatory response effector cells.As an immunoregulatory cytokine, IL-1β has the potential to enhance the immune response induced by a vaccine and/or to modulate the immune response leading to different effector mechanisms. It is produced by many cell types, including monocytes, macrophages,T and B lymphocytes, fibroblasts, and endothelial and epithelial cells. Expression is induced by a diverse range of stimuli, including mitogens, cytokines, and microbial products. There have been considerable evidences provided by biological cross reaction that fish produce IL-1β during immune responses, and the bioactivity of IL-1 in fish has been known for over a decade. But only. since 1999,IL-1β gene has been cloned from the rainbow trout. And from then on, IL-1β gene has been cloned and expressed in many fish confirming that fish produces IL-1β gene during immune responses. In mammals it is produced as an inactive precursor that is processed by interleukin converting enzyme (ICE) to give a biologically active ‘mature‘ peptide. There is no signal peptide in IL-1β and its mechanism is unknown. This is the special part of the gene structure of the IL-1β. And through the program analyzing, we found this special structure in fish IL-1β gene. This paper reviews the functions and structure of gene IL-1β and the studies of the gene IL-1β in fish recently.
|
关 键 词: | 细胞因子 白细胞介素1β 鱼类 |
文章编号: | 1000-0615(2005)01-0115-05 |
收稿时间: | 2014/3/13 0:00:00 |
修稿时间: | 2003年7月7日 |
本文献已被 CNKI 维普 万方数据 等数据库收录! |
| 点击此处可从《水产学报》浏览原始摘要信息 |
| 点击此处可从《水产学报》下载免费的PDF全文 |
|