| 多脂鳞伞菌丝体多糖抗肿瘤活性研究 |
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| 引用本文： | 赵永勋,李克颖,张跃华.多脂鳞伞菌丝体多糖抗肿瘤活性研究[J].食用菌学报,2007,14(2):49-54. |
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| 作者姓名： | 赵永勋 李克颖 张跃华 |
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| 作者单位： | 佳木斯大学生命科学学院,黑龙江佳木斯,154007 |
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| 摘 要： | 多脂鳞伞Pholiota adiposa(Fr.)Quel.]菌丝体多糖溶液给S-180荷瘤小鼠连续灌胃10d后,测定对荷瘤小鼠抑瘤率、碳粒廓清指数、小鼠外周血肿瘤坏死因子(TNF-α)和白介素-2(IL-2)含量的影响。结果发现,多脂鳞伞菌丝体多糖对荷瘤小鼠肿瘤的抑瘤率为39.54%,并可提高小鼠碳粒廓清指数,血清中IL-2和TNF-α的含量也明显提高。结果提示,多脂鳞伞菌丝体多糖抑制荷瘤小鼠的肿瘤生长可能与增强宿主的免疫功能相关。
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| 关 键 词： | 碳粒廓清指数 白介素-2 肿瘤坏死因子-α 多脂鳞伞 多糖 |
| 文章编号： | 1005-9873（2007）02-0049-03 |
| 收稿时间： | 2007-03-16 |
| 修稿时间： | 2007-03-162007-03-27 |
Anti-Tumor Function of Polysaccharides from Pholiota adiposa Mycelium |
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| ZHAO Yongxun,LI Keying,ZHANG Yuehua.Anti-Tumor Function of Polysaccharides from Pholiota adiposa Mycelium[J].Acta Edulis Fungi,2007,14(2):49-54. |
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| Authors: | ZHAO Yongxun LI Keying ZHANG Yuehua |
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| Institution: | College of Life Sciences, Jiamusi LI Keying, ZHANG Yuehua University, Jiamusi, Heilongjiang 154007, China |
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| Abstract: | Treatment of S-180 tumor-bearing mice with polysaccharide extracted from Pholiota adiposa mycelium resulted in lower tumor weights, increased carbon particle clearance and phagocytic indices, and significantly higher serum levels of TNF-α and IL-2, compared with untreated controls. Our data suggest that the anti-tumor activity of P. adiposa polysaccharide is related to immuno-enhancing activity. |
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| Keywords: | Carbon particle clearance index Interleukin-2 Pholiota adiposa Polysaccharide Tumor necrosis factor-alpha |
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