转移因子对鸡传染性喉气管炎灭活疫苗作用的研究

用ILT油乳剂灭活疫苗免疫雏鸡和蛋鸡,同时实验组肌注TF,于免疫后不同时间用ILT种毒攻击,并测定蛋鸡的淋巴细胞转化率。结果试验组于免疫后第5d产生保护力,第9d产生全保护(对照组分别为7d和11d),雏鸡和蛋鸡的保护期可达90d及180d,蛋鸡免疫后7d的淋巴细胞转化率达高峰48.7%,而对照组的为14d和38.5%,90d时分别为36.3%和28.5%。表明TF能提高ILT灭活疫苗的免疫效果,提高蛋鸡的细胞免疫机能,经统计学检验,对雏鸡免疫保护力无显著差异,而蛋鸡的差异显著(P<0.05)。

Effect of Transfer Factor on Inactivated Vaccines of Infectious Laryngotracheitis of Chickens

Chickens and layers were inoculated by Infectious Laryngotracheitis (ILT) Inactivated Vaccines,and the experiment groups also in jected by Transfer Factors (TF).It was challenged by ILT virus and determined the Lymphocyte transformation rate of layers in diffrenter time after immunization.The result was that specific immunity was established within 7 days and it could be completeprotectived 9 days later.In the control groups it was 5 days and 9 days.The protection duration in chickens was 90 d and that in layers was 180 d.The Lymphocyte transformation rate of layers peaks at 7 days Post-immunization and it was 48.7%.In the contorl groups,it was 14 days and 38.5%.That was 36.3% and 28.5% 90 days late.It was found tha tthe TF had an obvious efficacy at ILT inacti 2 vated vaccine,and the cellular immunity of layers could be improved too.A ccording to the test of statistics,different of protection of chickens was not clear,that was clear in layers (P<0.05).