|
|||||
|
|
Evaluation on the pathogenicity of Erysipelothrix tonsillarum for pigs by immunosuppression with cyclophosphamide or dexamethasone |
|
| Authors: | Kazuki Harada Masatake Muramatsu Shoko Suzuki Takuo Sawada Toshio Takahashi |
| Institution: | a National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1-15-1 Tokura, Kokubunji, Tokyo 185-8511, Japan b Department of Veterinary Microbiology, Nippon Veterinary and Life Science University, 1-7-1, Kyonan-cho, Musashino, Tokyo 180-8602, Japan c Research Institute for Animal Science in Biochemistry and Toxicology, 3-7-11, Hashimotodai, Sagamihara, Kanagawa 229-1132, Japan d Department of Health and Environmental Sciences, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan |
| Abstract: | The pathogenicity of Erysipelothrix tonsillarum was evaluated in pigs immunosuppressed with cyclophosphamide (CY) or dexamethasone (DM). Animals were treated with 15 mg/kg CY (n = 8, five injections), 1 mg/kg DM (n = 8, nine injections) or left untreated (n = 8). On the fifth day after the beginning of drug treatments, swine were inoculated with one of two E. tonsillarum serovar 7 strains (approximately 106 CFU per pig). In the CY-treated group, both circulating neutrophil and lymphocyte counts decreased, whereas in the DM-treated group, lymphocyte counts decreased but neutrophil counts increased. During the observation period, none of the CY- or DM-treated pigs developed clinical signs or gross lesions, as well as non-treated pigs. Growth agglutination antibody titres in all pigs remained unchanged. Our findings indicate that E. tonsillarum strains are avirulent for swine, regardless of immune status. |
| Keywords: | Avirulence Erysipelothrix tonsillarum Immunosuppression Swine erysipelas |
| 本文献已被 ScienceDirect 等数据库收录！ | |