| 枯草芽孢杆菌对仔猪小肠局部天然免疫及TLR表达的影响 |
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| 引用本文： | 李云锋,邓军,张锦华,杨倩.枯草芽孢杆菌对仔猪小肠局部天然免疫及TLR表达的影响[J].畜牧兽医学报,2011,42(4). |
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| 作者姓名： | 李云锋 邓军 张锦华 杨倩 |
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| 作者单位： | 南京农业大学动物医学院,农业部动物生理生化重点开放实验室,南京,210095 |
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| 基金项目： | 江苏省支撑计划(BE200830155); 国家自然科学基金项目(30871858) |
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| 摘 要： | 本研究主要探索枯草芽孢杆菌对仔猪小肠局部天然免疫及TLR表达的影响。选取4窝相同胎次的新生仔猪(15头)为研究对象。分别于仔猪0、7、14、26日龄灌喂枯草芽孢杆菌Bacillus subtilis(活菌数为1×108CFU.mL-1)。试验结果显示:枯草芽孢杆菌能够显著地促进十二指肠中TLR9和细胞因子IL-6的表达(P<0.05)以及回肠中细胞因子IL-1的表达(P<0.01),同时能够显著地提高仔猪小肠IgA分泌细胞的数量(P<0.01)。结果提示,枯草芽孢杆菌可能通过胞外成分激活小肠TLR9的表达后,诱导细胞因子IL-6的分泌,促进IgA分泌细胞数量增加。饲喂枯草芽孢杆菌具有促进新生仔猪小肠细胞免疫和体液免疫的作用,对预防新生仔猪腹泻提供了应用前景。
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| 关 键 词： | 枯草芽孢杆菌 仔猪 细胞因子 TLRs IgA分泌细胞 |
The Effects of Bacillus subtilis on Local Innate Immune and Expression of TLR of Pigs |
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| LI Yun-feng,DENG Jun,ZHANG Jin-hua,YANG Qian.The Effects of Bacillus subtilis on Local Innate Immune and Expression of TLR of Pigs[J].Acta Veterinaria et Zootechnica Sinica,2011,42(4). |
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| Authors: | LI Yun-feng DENG Jun ZHANG Jin-hua YANG Qian |
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| Institution: | LI Yun-feng,DENG Jun,ZHANG Jin-hua,YANG Qian (Key Laboratory of Animal Physiology and Biochemistry of Ministry of Agriculture,College of Animal Medicine,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | This experiment was conducted to study the effects of Bacillus subtilis on small intestine local mucosal immune responses and the expression of TLRs of pigs.The newborn piglets were orally administrated with Bacillus subtilis at 0,7,14,and 26 d after birth.The results showed that Bacillus subtilis could significantly promote the expression of TLR 9 and cytokine IL-6 in duodenum(P<0.05) and increase the quantity of IgA excreting cells(P<0.01),as well as increasing the expression of IL-1 in ileum(P<0.01).The ... |
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| Keywords: | Bacillus subtilis pig cytokine TLRs IgA excreting cell |
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