Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus |
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| Authors: | Ming-Hui Wang Xiao-Ming Li Chun-Shun Li Nai-Yun Ji Bin-Gui Wang |
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| Affiliation: | 1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails: (M.-H.W.); (X.-M.L.); (C.-S.L.);2.University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China;3.Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Chunhui Road 17, Yantai 264003, China |
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| Abstract: | Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and l-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5–10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 μM. |
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| Keywords: | sediment Penicillium pinophilum secondary metabolite brine shrimp lethality |
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