Thyroid hormones modulate the hypothalamo–hypophyseal–gonadal axis in teleosts: Molecular insights |
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Authors: | I Swapna B Senthilkumaran |
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Institution: | (1) Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India |
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Abstract: | Reproduction in fishes is influenced by thyroid hormones at various levels of gonadal cell differentiation and steroidogenesis.
Thyroid hormones have recently also emerged as an important modulator of season- and photoperiod-dependent variations in the
reproductive cycle with a possible effect on the hypothalamo–hypophyseal axis and pineal interactions. This review describes
the current status of thyroid hormone research in relation to reproduction, with special emphasis on contributions to this
field by Indian researchers including our laboratory. Evidence is provided for the multifocal action of thyroid hormones at
various levels of the hypothalamo–hypophyseal–gonadal axis affecting reproduction. The underlying physiological and molecular
mechanisms pertaining to thyroid hormone modulation of reproduction, such as gonadotropin-releasing hormone (GnRH) synthesis
and release, androgen and gonadotropin receptor expression, gonadotropin (GTH) expression, and tissue sensitivity to GTHs
are highlighted with relevant discussions of the current technical limitations, applications, and future perspectives of research
in this field. |
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Keywords: | Thyroid hormones Thyroid hormone receptors Teleosts Gonadotropin-releasing hormone Gonadotropins Sex steroids |
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