| Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene （LHCGR） with superovulation traits in Chinese Holstein heifers |
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| 引用本文： | Yong Yu,Yunwei Pang,Haichao Zhao,Xiaoling Xu,ZhonghongWu Lei,An Jianhui,Tian. Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene （LHCGR） with superovulation traits in Chinese Holstein heifers[J]. 畜牧与生物技术杂志(英文版), 2012, 3(4): 188-192 |
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| 作者姓名： | Yong Yu Yunwei Pang Haichao Zhao Xiaoling Xu ZhonghongWu Lei An Jianhui Tian |
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| 作者单位： | Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China |
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| 基金项目： | Acknowledgements We thank Yulin Zhu and Bohua Xuan of the Beijing Dairy Cattle Center for their help in sampling and collecting data from the heifers. We are also grateful to Dr. Qin Zhang for help with the statistical analyses. This study was supported by grant #2011BAD19B01, #2011 BAD19B03 and #2011 BAD19B04 from the National Key Technology R＆D program; #2011AA100303 from National High-Tech R＆D Program. |
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| 摘 要： | Background: Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function. We detected mutations in the LHCGR gene and evaluated their association with superovulation. Methods: Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing, we examined polymorphisms in LHCGR and the genotypes associated with superovulation traits in 127 Chinese Holstein heifers. Results: A G/T polymorphism (ss52050737) in exon 11 was significantly associated with the total number of ova and the number of transferable embryos. Conclusions: LHCGR may be a new predictor for superovulation in Chinese Holstein heifers.
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| 关 键 词： | Chinese Holstein heifer LHCGR SNP Superovulation |
Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers |
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| , Yong Yu , Yunwei Pang , Haichao Zhao , Xiaoling Xu , Zhonghong Wu , Lei An , Jianhui Tian. Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers[J]. Journal of Animal Science and Biotechnology, 2012, 3(4): 188-192 |
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| Authors: | , Yong Yu , Yunwei Pang , Haichao Zhao , Xiaoling Xu , Zhonghong Wu , Lei An , Jianhui Tian |
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| Affiliation: | Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China |
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| Abstract: | |
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| Keywords: | Chinese Holstein heifer LHCGR SNP Superovulation |
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