交联辛烯基琥珀酸淀粉酯微球对阿司匹林的吸附性能研究

采用反相微乳法制备交联辛烯基琥珀酸淀粉酯微球,利用红外光谱、粒度分析仪、扫描电镜和X射线衍射仪对微球进行表征,研究微球对阿司匹林的吸附性能,采用单因素固定变量法探讨投药量、交联剂用量、反应时间对吸附量的影响。结果表明:原淀粉已成功酯化交联合成变性淀粉微球,微球平均粒径为42.61μm,粒径在80μm以下占93.7%;微球表面粗糙多孔,外观圆整,由原淀粉颗粒的晶体形态变为无定性态;在交联剂用量1.5 g,反应时间3.5 h,投药量22 mg的最佳制备条件下,微球的载药量达到21.48%,包封率达到97.63%,可以作为一种优良的阿司匹林吸附载体。

Study on Adsorption Behaviors of Crosslinked Octenyl Succinic Anhydride Modified Starch Microspheres for Aspirin

Crosslinked octenyl succinic anhydride modified starch microspheres were synthesized by inverse microemulsion method.Fourier transform infrared spectro-scopy(IR),granularity analyzer,scanning electron microscopy(SEM) and X-ray diffractometer were used to characterize the modified starch microspheres.The adsorb ability of the modified starch microspheres for aspirin was studied,and the influence of factors such as reagent dosage,cross-linking agent dosage,reaction time on adsorption quantity was discussed by single factor fixed variable method.The results showed that: the starch has been successfully synthesized to modified starch microspheres by esterification and cross-linking reaction.The average diameter of modified starch microspheres was 42.61 μm,the modified starch microspheres of diameter below 80 μm reached 93.7%.The surface of modified starch microspheres was rough,porous and round,its form became amorphous from crystal of cassava starch.In the optimum preparation condition of cross-linking agent dosage 1.5 g,reaction time 3.5 h,reagent dosage 22 mg,the drug loading quantity of modified starch microspheres reached 21.48%,envelopment rate reached 97.63%.So the modified starch microspheres could be used as one of excellent drug carriers for aspirin.