连花柴芩可溶性粉解热镇痛止咳祛痰作用的研究

为评价连花柴芩可溶性粉的解热、镇痛、止咳、祛痰作用,采用LPS致大鼠发热法、醋酸致小鼠扭体法、小鼠氨水引咳法、小鼠气管段酚红排泌法,观察连花柴芩可溶性粉的解热、镇痛、止咳、祛痰作用。结果显示,连花柴芩可溶性粉抑制大鼠发热效果显著(P0.05);减少小鼠扭体反应次数(P0.05),镇痛率分别为34.81%、32.59%和27.31%;减少小鼠咳嗽次数(P0.05),抑制率分别为36.82%、31.48%和20.37%;能增强小鼠对酚红的排泌(P0.05)。表明连花柴芩可溶性粉具有明显的解热、镇痛、止咳、祛痰的作用。

Study on Antipyretic, Analgesic, Antitussive and Expectorant Effects of Lian-hua-chai-qin Soluble Powder

To study the antipyretic, analgesic, antitussive and expectorant effects of Lian-hua-chai-qin Soluble Powder (LHCQSP) to provide reasonable experimental reference for clinical. The antipyretic activity was evidenced in fever rats induced by LPS. Analgesic activity was tested in mice induced by acetic acid. Antitussive effect was examined in mice induced by ammonia, the tracheal phenol red secretion test in mice was for expectorant activity. LHCQSP obviously depressed the temperature of fever rats (P<0.05), decreased twist times of mice by 34.81%, 32.59% and 27.31%, respectively (P<0.05), reduced cough times of mice by 36.82%, 31.48% and 20.37% , respectively (P<0.05), increased the amount of secreting phenol red (P<0.05). This experiment shows that LHCQSP possess antipyretic, analgesic, antitussive and expectorant effects in model animal.