抗病毒免疫中宿主细胞的自溶作用以及病毒的进化

多种病原体能够侵害宿主细胞并从宿主的机体免疫系统的防御下得以逃逸。在宿主细胞中,病原体利用一些复杂的方法和途径避免了细胞对入侵者强有力的攻击。近年来的研究表明,自噬作用是细胞内宿主细胞杀灭入侵病原微生物的防御结构中最显著的工具之一,有些病原体却可以在分子水平阻滞这种自噬通路而使持续感染成为可能。宿主抗病毒反应中自噬作用与先天免疫和获得性免疫之间,以及病毒与自噬作用之间存在着复杂的相互关系,这些关系主导了自噬作用和病原菌之间的相互作用。

Autophagy in Host Cells and Evolution Strategy of Virus in Anti-virus Immunity

Numerous pathogens have possessed the capacity to invade host cells protected from components of the systemic immune system.However,once in the host cells pathogens utilize sophisticated strategies to avoid the powerful machinery built by the host cells to kill invading pathogens.There are cumulative evidence indicating that autophagy is one of the most remarkable tools of the intracellular host cell defense machinery that bacteria must confront upon cell invasion in the last few years.However,several patho...