Cutaneous vascular malformation in a guinea pig (Cavia porcellus) |
| |
Authors: | Osofsky Anna De Cock Hilde E V Tell Lisa A Norris Aimee J White Stephen D |
| |
Affiliation: | Veterinary Medical Teaching Hospital,;Department of Pathology, Microbiology, and Immunology,;Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA |
| |
Abstract: | Abstract A skin lesion classified as a vascular malformation is reported in a young-adult, female guinea pig. The physical examination revealed a 3 × 2-cm irregularly shaped violaceous plaque located on the left caudal flank. The surface of the plaque was ulcerated and bled intermittently, resulting in fatal blood loss. On histology the mass consisted of variably sized vascular spaces filled with red blood cells and variable amounts of extramedullary haematopoietic cells, lined by well-differentiated endothelial cells often surrounded by one layer of spindle-shaped cells. Based on immunohistochemistry, the spindle cell population was confirmed to be smooth muscle cells and no proliferation of endothelial cells was found with the Ki67 proliferation marker. Histological and immunohistochemical findings were consistent with a vascular malformation. Classification of vascular malformations and potential treatments are discussed. To the authors' knowledge, this is the first reported case of a cutaneous vascular lesion in a guinea pig. |
| |
Keywords: | arterial guinea pig skin vascular malformation |
本文献已被 PubMed 等数据库收录! |
|