Gastric pleomorphic leiomyosarcoma in a Shetland sheepdog |
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Authors: | Park Chun-Ho Ishizuka Yousuke Tsuchida Yasuhiko Oyamada Toshifumi |
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Institution: | Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Amori, Japan. |
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Abstract: | A solitary mass of 6 x 6 x 5 cm was found in the smooth muscle layer of the pyloric part in the stomach of a Shetland sheepdog. The excised mass was solid, gray-white in color, and had central necrosis with hemorrhages. Microscopically, the neoplasm was composed of irregular bundles of spindle-shaped tumor cells and round tumor cells. A few multinucleated cells and gangliocyte-like cells were observed. The nuclei exhibited a high degree of atypia and many cells contained mitotic figures. Immunohistochemically, tumor cells were positive for vimentin and desmin, but negative for c-kit antibody. Ultrastructurally, tumor cells contained cytoplasmic myofilaments and pinocytotic vesicles. Based on these pathological findings, the tumor was diagnosed as gastric pleomorphic leiomyosarcoma. |
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