| PRRSV逃逸宿主天然免疫的分子机制 |
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| 引用本文： | 吴俊静,乔木,彭先文,武华玉,刘贵生,梅书棋.PRRSV逃逸宿主天然免疫的分子机制[J].黑龙江农业科学,2013(12):58-61. |
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| 作者姓名： | 吴俊静 乔木 彭先文 武华玉 刘贵生 梅书棋 |
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| 作者单位： | 湖北省农业科学院畜牧兽医研究所,湖北武汉430064 |
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| 基金项目： | 湖北省农业科学院青年基金资助项目（2013NKYJJ11）;动物胚胎工程及分子育种湖北省重点实验室资助项目（2013ZD101） |
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| 摘 要： | 猪繁殖与呼吸综合症病毒（PRRSV）可破坏机体的天然免疫系统，导致猪的免疫抑制，进而导致继发感染或混合感染，为进一步研究PRRSV逃逸宿主天然免疫的分子机制，综述了PRRSV抑制I型IFN的激活及其相关信号通路，逃逸宿主天然免疫系统的多种途径，从而避免PRRSV侵染，为PRRSV的防控提供分子基础。
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| 关 键 词： | PRRSV 天然免疫 干扰素 |
Molecular Mechanisms of Escaping Host Innate Immune Systems of PRRSV |
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| WU Jun-jing,QIAO Mu,PENG Xian-wen,WU Hua-yu,LIU Gui-sheng,MEI Shu-qi.Molecular Mechanisms of Escaping Host Innate Immune Systems of PRRSV[J].Heilongjiang Agricultural Science,2013(12):58-61. |
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| Authors: | WU Jun-jing QIAO Mu PENG Xian-wen WU Hua-yu LIU Gui-sheng MEI Shu-qi |
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| Institution: | (Institute of Animal Science and Veterinary Medicine, Hubei Provincial Academy of Agricul rural Sciences, Wuhan, Hubei 430064) |
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| Abstract: | Porcine Reproductive and Respiratory Syndrome（PRRS）could destroy innate immune system of pigs, made immune suppression and lead to secondary infection or mixed infection. In order to study the molecular mechanism of PRRSV escaping host innate immune, various pathways of inhibiting the activation of type I in- terferons and related signaling pathways to avoid the infection of PRRSV in pigs, so as to provide molecular ba- sis for the prevention and control of PRRSV. |
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| Keywords: | PRRSV innate immune interferon |
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