| 茶多酚对家兔C-BSA肾炎的治疗作用 |
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| 引用本文： | 胡秀芳,黄辛蕾,杨贤强,陈集双.茶多酚对家兔C-BSA肾炎的治疗作用[J].浙江大学学报(农业与生命科学版),2001,27(5):569-574. |
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| 作者姓名： | 胡秀芳 黄辛蕾 杨贤强 陈集双 |
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| 作者单位： | 1. 浙江大学,生物科学系,浙江,杭州,310029
2. 浙江大学,茶学系,浙江,杭州,310029 |
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| 基金项目： | 浙江省自然科学基金资助项目(398505) |
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| 摘 要： | 考察了茶多酚对家兔C-BSA肾炎的治疗作用.结果表明:茶多酚大(306 mg/kg)、中(102 mg/kg)、小(34mg/kg)剂量组及地塞米松阳性对照组均能明显降低C-BSA肾炎模型免的尿蛋白和血清肌酐(P＜0.05或P＜0.01);减轻肾小球肿胀、细胞增生、血栓形成及白细胞浸润,修复肾小球病理改变;降低血清循环免疫复合物(P＜0.05).茶多酚大剂量的作用优于阳性对照药地塞米松(0.1 mg/kg,P＜0.05),并且大、小剂量间差异显著,有明显的剂量相关性.结果提示:茶多酚对家免C-BSA肾炎模型具有明显的疗效.
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| 关 键 词： | 茶多酚 家兔 C-BSA肾炎 疗效 |
| 文章编号： | 1008-9209(2001)05-0569-06 |
Effects of Tea Polyphenols on C-BSA-Nephritis Rabbits . |
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| HU Xiu fang ,Huang Xing lei ,YANG Xian qiang ,CHEN Ji shuang.Effects of Tea Polyphenols on C-BSA-Nephritis Rabbits .[J].Journal of Zhejiang University(Agriculture & Life Sciences),2001,27(5):569-574. |
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| Authors: | HU Xiu fang Huang Xing lei YANG Xian qiang CHEN Ji shuang |
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| Institution: | HU Xiu fang 1,Huang Xing lei 1,YANG Xian qiang 2,CHEN Ji shuang 2 |
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| Abstract: | Tea polyphenols was investigated to alleviate the symptom of C BSA Nephrites rabbits in dose dependent manner(large dose 306 mg/kg; middle dose 102 mg/kg; small dose 34 mg/kg) It reduced the urine protein and serum inosine ( P <0 05 or P <0 01); alleviated the glomerulus swelling,cells proliferation,thrombosis and leukocyte infiltration; repaired the pathological changes of renal tubule; decreased the circling immunity complex (CIC, P <0 05) The effect of large dose tea polyphenols was significantly different from small dose tea polyphenols,and was better than that of DSMS So large dose tea polyphenols may be useful for therapy of nephritis |
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| Keywords: | tea polyphenols rabbit C BSA neqhritis therapy |
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