Plasma and platelet serotonin concentrations in healthy dogs and dogs with myxomatous mitral valve disease |
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| Affiliation: | 1. Department of Equine and Small Animal Medicine, University of Helsinki, Box 57, 00014 Helsinki, Finland;2. Minerva Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, 00290 Helsinki, Finland;3. Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, S-750 07 Uppsala, Sweden;4. The Royal Veterinary and Agricultural University, Copenhagen, Denmark;5. Faculty of Medicine, Hjelt Institute, University of Helsinki, Box 40, 00014, Finland;6. Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Box 7011, S-750 07 Uppsala, Sweden;1. Physikalisches Institut and Bethe Center for Theoretical Physics, Universität Bonn, Nussallee 12, D-53115 Bonn, Germany;2. Department of Physics, King''s College London, London WC2R 2LS, UK;3. Kavli Institute for the Physics and Mathematics of the Universe (WPI), TODIAS, University of Tokyo, Kashiwa 277-8568, Japan;1. Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA;2. Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Surgery, Columbia Cardiovascular Institute and College of Physicians and Surgeons at Columbia University, New York, NY, USA;4. The Children''s Hospital of Philadelphia, Philadelphia, PA, USA;1. Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand;2. Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand;3. Department of Clinical Sciences, Colorado State University, CO 80523, USA;1. Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, Spain;2. Unidad de Alergia Cutánea y Fotoparche, Servicio de Dermatología, Complejo Hospitalario Universitario de Vigo, Vigo, Spain;3. Servicio de Dermatología, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain |
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| Abstract: | ObjectivesSerotonin has been implicated in canine myxomatous mitral valve disease (MMVD); however, the sources of serotonin have not been fully elucidated. This study compared the concentration of serotonin in plasma and platelets of normal healthy small breed dogs with predisposition to MMVD and dogs with naturally occurring MMVD.Animals43 small-breed client-owned dogs with an approximate weight of <10 kg and age of 6 years or above were divided into 2 groups: a healthy control group (n = 20) and a group with echocardiographic evidence of MMVD (n = 23).Methods5 ml samples of blood were collected. Plasma and platelets were separated by centrifugation and assayed for serotonin measured by enzyme linked immunosorbent assay (ELISA).ResultsMedian plasma serotonin concentration was not significantly different (p = 0.3630) between normal healthy dogs (3.7 ng/ml) and dogs with MMVD (4.3 ng/ml). Males had higher plasma serotonin concentration than females (4.7 and 2.9 ng/ml respectively, p = 0.0043). Platelet serotonin concentration was not different between healthy dogs and dogs with MMVD (128.6 ng/109 platelets and 176.6 ng/109 platelets respectively, p = 0.4575). Age, echocardiographic indices and platelet count showed no correlation with plasma or platelet serotonin concentration.ConclusionsCirculating plasma serotonin is unlikely a major source of serotonin signaling in canine MMVD. Platelets could be a source of serotonin in canine MMVD through platelet adhesion to the mitral valve; however, the amount of serotonin stored in platelets of healthy dogs and dogs with MMVD is not different. |
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| Keywords: | Canine Circulation Degenerative mitral valve disease Heart Pathogenesis |
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