Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha |
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| Authors: | Xu Jing Guo Yuanqiang Zhao Peng Xie Chunfeng Jin Da-qing Hou Wenbin Zhang Tiejun |
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| Institution: | aCollege of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China;bTianjin Children's Hospital, Tianjin 300074, China;cSchool of Medicine, Nankai University, Tianjin 300071, China;dTianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Three new cadinane sesquiterpenes, commiterpenes A−C (1−3), were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). All the isolated sesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells. |
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| Keywords: | Cadinane Sesquiterpene Commiphora myrrha Neuroprotective effect |
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